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作者报道5例慢性粒细胞白血病(CML)使用小剂量马利兰并用硫鸟嘌呤治疗后出现食管静脉曲张及肝功能异常。5例中男3例、女2例,年龄42～81岁。所有病人都接受了硫鸟嘌呤治疗。用法:马利兰2mg/d,硫鸟嘌呤(6-TG)80mg/d,两种药每周均口服5天。直至白细胞总数达10 000～20 000/mm~3,然后调整每周服药的天数,使白细胞维持在5 000～
The authors report 5 cases of chronic myeloid leukemia (CML) using low-dose of marilan and thioguanine treatment of esophageal varices and liver dysfunction. 5 males in 3 cases, 2 females, aged 42 to 81 years old. All patients received thioguanine treatment. Usage: Malilan 2mg / d, thioguanine (6-TG) 80mg / d, two kinds of drugs are taken orally five days a week. Until the total number of white blood cells up to 10 000 ~ 20 000 / mm ~ 3, and then adjust the number of days a week medication to maintain white blood cells in 5000 ~