论文部分内容阅读
一、组胺及其受体分型组胺(HisTamine,HA)是组氨酸脱羧产物,在哺乳动物中以心脏、肝脏、胃肠道、肺脏及肥大细胞含量最多。实验证明,在致敏动物遭受相应抗原刺激时,敏感化的器官有组胺或组胺样物质释放。也曾发现,犬在发生过敏性休克时,血中组胺含量增加,而且所增加的量与休克症状的严重程度相平行。用组胺释放剂,如48/80注射于动物或人,也可出现类似变态反应的症状。上述事实提示人们寻找组胺各种反应的对抗剂找到了方
First, histamine and its receptor type histamine (HisTamine, HA) is a histidine decarboxylation product in mammals to the heart, liver, gastrointestinal tract, lungs and mast cells most. Experiments show that when sensitized animals are exposed to the corresponding antigenic stimuli, the sensitized organ has histamine or histamine-like substances released. Hamsters have also been found in dogs in the event of anaphylactic shock, blood histamine levels increased, and the increase in the severity of the symptoms of shock in parallel. Symptoms similar to allergies can also occur with histamine release agents, such as 48/80 injection in animals or humans. The above facts prompted people to look for antagonists of histamine various reactions found