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用组织化学和免疫组织化学方法检测肝细胞癌(HCC)、肝细胞不典型增生(LCD)和癌旁非LCD的γ-GT酶、甲胎蛋白、癌胚抗原和铁蛋白4种肿瘤标志的表达情况。发现HCC、LCD和癌旁非LCD肝细胞均有不同程度表达。与HCC相比,LCD的肿瘤标志表达更接近于癌旁非LCD肝细胞,但又有所不同,提示LCD是一组增生性病变,有轻有重,性质和程度都不尽相同。轻的,其生物学性质接近于正常肝细胞;重的与癌前病变有某些相似之处。
Histochemical and immunohistochemical methods for the detection of four tumor markers of hepatocellular carcinoma (HCC), hepatocellular atypical hyperplasia (LCD) and paracancerous non-LCD gamma-GTase, alpha fetoprotein, carcinoembryonic antigen, and ferritin Expression of situation. It was found that HCC, LCD, and paracancerous non-LCD hepatocytes have different degrees of expression. Compared with HCC, the expression of tumor markers on LCDs is closer to that of non-LCD liver cells, but it is different. It suggests that LCD is a group of proliferative lesions, which are light and heavy, and have different properties and degrees. Light, its biological properties are similar to normal liver cells; heavy and precancerous lesions have some similarities.