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目的 探讨早期乳腺癌乳腺保全性手术时腋窝淋巴结清扫与不清扫对治疗结果的影响。方法 将66 例Ⅰ~Ⅱ期乳腺癌行乳腺功能保全性手术的患者分为2 个组:乳腺肿块局部切除+腋窝清扫组( 局部切除+ 腋清组)36 例和乳腺肿块局部切除组30 例。所有病例均用乳腺切线野给予锁骨上下区、腋窝、内乳淋巴链区照射,瘤床行推量补充照射。结果 临床检查腋窝淋巴结阴性的28例,术后病理证实为阳性的6 例(21.4 % );T1 ,T2 期病例腋窝淋巴结阳性率分别为30.0% (6/20) ,43.8% (7/16) 。局部切除+ 腋清组和局部切除组乳腺复发分别为4 例(11.1% ) 和7 例(23.3% ) ,区域淋巴结复发分别为2 例和3 例,2 个组乳腺局部和区域淋巴结复发率差异无显著意义( P> 0 .05) 。局部切除+ 腋清组和局部切除组远地转移分别为6 例(16 .6% ) 和7 例(23.3% )( P> 0.05)。局部切除+ 腋清组与局部切除组的总生存率和无瘤生存率经KaplanMeier 法分析,Logrank 检验差异无显著意义。局部切除+ 腋清组和局部切除组上肢浮肿发生率分别为12 例(33 .4% ) 和5 例(16.7 %) 。结论 在早期乳腺癌乳腺保全性手术+ 术后放射治疗中,腋窝淋巴结清扫对腋窝淋巴结阴性的T1 期和部分T2 期病例是不必要的,原发灶局部切除术后区域淋巴结放射治疗可达到与腋窝清扫
Objective To investigate the effect of axillary lymph node dissection and non-sweeping cleansing on outcomes of breast cancer in early breast cancer. Methods Sixty-six patients with stage I to stage II breast cancer undergoing breast function preservation surgery were divided into two groups: local resection of breast mass + axillary dissection group (local resection + Minqing group) in 36 cases and local resection of breast mass in 30 cases . All cases were treated with mammary gland tangential field to give upper and lower clavicle region, axillary fossa and internal breast lymph node region. Results Twenty-six patients with negative axillary lymph nodes and 6 postoperative pathologically confirmed cases (21.4 %) were negative. The positive rates of axillary lymph nodes in T1 and T2 cases were 30.0% (6/20) and 43.8% (7/16), respectively. . The recurrences of breast resection in the local resection+Sakura group and local resection group were 4 cases (11.1%) and 7 cases (23.3%) respectively. The recurrence of regional lymph nodes was 2 cases and 3 cases respectively. The recurrence rates of local and regional lymph nodes in the 2 groups were different. No significant significance (P > 0.05). Local resection + distant metastases in the Minqing group and the local resection group were 6 cases (16.6%) and 7 cases (23.3%), respectively (P> 0.05). The overall survival rate and disease-free survival rate of the local resection+Sacral clear group and local resection group were analyzed by Kaplan-Meier method. Log-rank test showed no significant difference. The incidence of upper extremity edema in the local resection+Sakura group and local resection group was 12 cases (33.4%) and 5 cases (16.7 %), respectively. Conclusions Axillary lymph node dissection is not necessary for T1 stage and T2 stage cases of axillary lymph node-negative surgery in early stage mammary gland surgery and postoperative radiotherapy. Regional lymph node radiotherapy after local resection can achieve Swab cleaning