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目的研究双参通冠方(SSTG)对心肌缺血再灌注模型大鼠炎症因子及血管内皮功能的影响。方法采用大鼠心肌缺血再灌注模型,随机分为假手术组、模型组、SSTG高剂量组和SSTG低剂量组,每组8只,灌胃给药,SSTG高剂量组8 g/kg、SSTG低剂量组4 g/kg,2次/d,连续给药14 d后检测血清NO、ET的水平和心肌组织TNF-α、IL-6、IL-8的水平。结果 与假手术组比较,模型组的TNF-α、IL-6、IL-8、ET水平均升高,差异有统计学意义(P<0.05)。与模型组比较,SSTG低剂量组和SSTG高剂量组TNF-α、IL-6、IL-8、ET水平均降低,NO升高,差异有统计学意义(P<0.05)。与SSTG低剂量组比较,SSTG高剂量组TNF-α、IL-6、IL-8、ET、NO改变更明显(P<0.05)。结论 双参通冠方对心肌缺血再灌注损伤具有一定的保护作用。其作用机制可能与抑制炎症因子反应和改善血管内皮物质释放有关。
Objective To study the effects of Shuangshentonggan Decoction (SSTG) on inflammatory factors and endothelial function in myocardial ischemia-reperfusion model rats. Methods The model of myocardial ischemia-reperfusion in rats was randomly divided into sham operation group, model group, high-dose SSTG group and low-dose SSTG group. Each group was given 8 mg / kg SSTG high- The serum levels of NO and ET and the levels of TNF-α, IL-6 and IL-8 in myocardium were detected by low dose SSTG 4 g / kg, twice daily for 14 days. Results Compared with the sham operation group, the levels of TNF-α, IL-6, IL-8 and ET in model group were significantly increased (P <0.05). Compared with the model group, the levels of TNF-α, IL-6, IL-8 and ET in the SSTG low-dose group and the high-dose SSTG group were both decreased, while the NO level was increased. The difference was statistically significant (P <0.05). The levels of TNF-α, IL-6, IL-8, ET and NO in high-dose SSTG group were significantly higher than those in low-dose SSTG group (P <0.05). Conclusion Shuangshen Tongguan Decoction has a protective effect on myocardial ischemia-reperfusion injury. Its mechanism may be related to the inhibition of inflammatory cytokines and the improvement of vascular endothelial material release.