目的 :探讨武汉地区气传致敏真菌与变应性鼻炎的发病关系 ,以指导其预防、诊断和治疗。方法 :对门诊就医的 392例变应性鼻炎患者 (鼻炎组 )进行致敏原皮试检测 ,同时用 15种当地常见真菌进行分类皮试 ;采用酶联免疫吸附实验 (ELISA)法进行血清总IgE水平测定 ,并与 85例健康志愿者 (对照组 )比较。结果 :392例患者中 2 39例真菌皮试阳性 (6 0 .97% ) ,其阳性率明显高于对照组 (7.0 6 % ) ,χ2 =80 .4 9,P <0 .0 1;血清总IgE水平亦明显高于对照组 (t=5 .4 7,P<0 .0 1)。当地主要气传致敏真菌为根霉、弯孢霉、交链孢霉等。结论 :气传致敏真菌是变应性鼻炎的重要致敏原之一。 Objective: To investigate the relationship between airborne allergenic fungi and allergic rhinitis in Wuhan to guide its prevention, diagnosis and treatment. Methods: 392 allergic rhinitis patients (rhinitis group) were investigated by allergen skin test, and 15 kinds of local common fungi were used for skin test. Serum total IgE was detected by enzyme linked immunosorbent assay (ELISA) The levels were measured and compared with 85 healthy volunteers (control group). Results: A total of 239 392 cases of fungal skin test positive (60.97%), the positive rate was significantly higher than the control group (7.06%), χ2 = 80.49, P <0.01; serum The total IgE level was also significantly higher than the control group (t = 5.47, P <0.01). Local main allergenic fungi Rhizopus, Curvularia, Alternaria Alternaria and so on. Conclusion: Airborne allergen is one of the important allergens of allergic rhinitis.