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淋巴瘤的发生、发展是一个受自身遗传免疫及多种外界因素相互作用而引起多种遗传学改变并逐渐积累的过程。EBV是多种淋巴瘤的重要致瘤因素,因而其病毒基因结构和功能的研究一直是淋巴瘤病因发病学研究领域中的重点。本文就EBV相关基因及编码蛋白的功能以及它们在淋巴瘤发病中的作用进行综述。
The occurrence and development of lymphomas is a process that causes many genetic changes and gradually accumulates due to their own genetic immunity and the interaction of various external factors. EBV is an important tumorigenic factor of many kinds of lymphomas. Therefore, the study of its viral gene structure and function has been the focus in the field of etiology of lymphoma. This review summarizes the functions of EBV-related genes and their encoded proteins and their role in the pathogenesis of lymphoma.