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目的 :探讨肝欣液保肝降酶的作用。方法 :用肝欣液的两种浓度 ,小鼠连续灌胃 7天 ,用四氯化碳(CCl4 )诱发小鼠肝损伤 ,以生理盐水作空白对照和CCl4 肝损伤作模型对照 ,作血清谷丙转氨酶 (SGPT)检测和病理组织观察。结果 :肝欣液大小两个剂量组SGPT数值略高于空白对照组 ,但无统计学差异 (P >0 0 5 ) ,而与模型对照组比较 ,则SGPT显著下降 (P <0 0 1) ;病理观察 :肝欣液大小剂量组小鼠肝细胞损伤性病变较轻 ,大剂量组病变又轻于小剂量组。结论 :肝欣液大小剂量组均能对抗CCl4 所致小鼠SGPT增高 ,减轻肝组织的病理性损伤 ,尤以大剂量组效果更为突出 ,有明显的保肝降酶作用。
Objective :To explore the effect of Liver-Liquor on hepatoprotective enzymes. METHODS: At two concentrations of liver-stimulating solution, mice were continuously intragastrically administered for 7 days and liver injury was induced with carbon tetrachloride (CCl4). Normal saline was used as a control and CCl4 liver injury as a model control. Alanine aminotransferase (SGPT) detection and histopathological observation. RESULTS: The SGPT value was slightly higher in the two dose groups than in the blank control group, but there was no statistical difference (P > 0.05). Compared with the model control group, the SGPT was significantly decreased (P <0 01). Histopathological observation: The hepatic cell injury lesions in the liver and liver liquid dose group were lighter, and the lesions in the high dose group were lighter than the low dose group. Conclusion : The liver and liver liquid size and dose group can resist the increase of SGPT induced by CCl4 in mice and reduce the pathological damage of liver tissue, especially in the high-dose group, the effect is more prominent, there is a significant role in liver protection and down-regulation.