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目的报道1例静脉滴注胺碘酮致肝肾功能不全患者。方法 2010年10月收治1例扩张性心肌病患者,治疗过程中使用胺碘酮注射液,导致严重的肝肾功能不全。系统查阅中国期刊全文数据库及外文数据库Pubmed、Embase建库至2011年8月关于胺碘酮致肝肾功能不全的相关文献,进行静脉胺碘酮致肝肾功能不全的可能性评估,探索胺碘酮静脉滴注致肝功能不全的的作用机制。结果根据查阅文献结果分析,此患者静脉注射胺碘酮致肝功不全的可能性高,Naranjo概率评分分别为7分。结论提出临床医师和临床药师应进行胺碘酮静脉的药学监护,高度的重视胺碘酮相关的不良反应,从而及时识别和防治胺碘酮所致肝肾功能不全,减少其不良预后。
Objective To report a case of intravenous infusion of amiodarone in patients with liver and kidney dysfunction. Methods One patient with dilated cardiomyopathy was admitted in October 2010. Amiodarone injection was used in the course of treatment, which resulted in severe liver-kidney dysfunction. System access to Chinese Journal Full-text Database and foreign databases Pubmed, Embase database to August 2011 on amiodarone-induced liver and kidney dysfunction in the literature, the possibility of intravenous amiodarone induced liver and kidney dysfunction, to explore the amiodarone Mechanism of hepatic insufficiency caused by intravenous ketones infusion. Results According to the literature review, the risk of hepatic insufficiency caused by intravenous amiodarone was high in this patient. The Naranjo probability score was 7 points. Conclusions It is suggested that clinicians and clinical pharmacists should carry out the drug monitoring of amiodarone intravenous injection and attach great importance to amiodarone-related adverse reactions so as to identify and prevent liver and renal insufficiency caused by amiodarone in time and reduce their adverse prognosis.