研究表明,细胞外基质(E CM)的代谢失衡与肾脏疾病密切相关。参与肾脏ECM降解的酶主要有丝氨酸蛋白酶、半胱氨酸蛋白酶和基质金属蛋白酶(M M Ps)。其中M M Ps可协同降解多种EC M成分,发现M M Ps不仅参与ECM代谢的调控,在疾病状态下ECM的重塑中也起着重要的作用,并且与活动性炎症 Studies have shown that the metabolic imbalance of extracellular matrix (E CM) is closely related to kidney disease. Enzymes involved in the degradation of renal ECM are serine protease, cysteine ​​protease and matrix metalloproteinases (M M Ps). Among them, M M Ps can synergistically degrade multiple ECM components. It was found that M M Ps not only involved in the regulation of ECM metabolism, but also plays an important role in the remodeling of ECM in disease states, and is also associated with active inflammation