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目的对左旋卡尼汀治疗扩张型心肌病的临床疗效进行观察分析。方法缺血性心肌病慢性心力衰竭患者48例,随机分为两组,对照组常规治疗,治疗组在常规治疗基础上加用左旋卡尼汀,并比较疗效。结果对照组总有效率60.0%,治疗组总有效率88.2%,两组比较差异有统计学意义(P<0.05)。各组治疗前、后心率(HR)和血压差异有统计学意义(P<0.05);两组HR和血压在治疗前及治疗后比较,差异均无统计学意义(P>0.05)。两组心输出量和左室射血分数(LVEF)在治疗前及治疗后比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上给予左旋卡尼汀治疗,可以改善扩张型心肌病患者的心功能,显著降低BNP水平。
Objective To observe and analyze the clinical efficacy of L-carnitine in the treatment of dilated cardiomyopathy. Methods 48 cases of patients with chronic heart failure of ischemic cardiomyopathy were randomly divided into two groups, the control group conventional treatment, the treatment group on the basis of conventional treatment plus L-carnitine, and compare the curative effect. Results The total effective rate of the control group was 60.0%, and the total effective rate of the treatment group was 88.2%. There was significant difference between the two groups (P <0.05). There were significant differences in heart rate (HR) and blood pressure before and after treatment in each group (P <0.05). There was no significant difference in HR and blood pressure before and after treatment between the two groups (P> 0.05). There was no significant difference in cardiac output and left ventricular ejection fraction (LVEF) before and after treatment between two groups (P> 0.05). Conclusions L-carnitine can improve cardiac function and decrease BNP in patients with dilated cardiomyopathy on the basis of routine treatment.