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研究了经口慢性给予钒酸钠对糖尿病大鼠组织自由基防御机制的影响。钒酸钠放入佳水中,浓度分别为0.1mg/ml和0.2mg/ml.共饮用5周。研究结果表明,钒酸钠处理对糖尿病大鼠肝脏还原型谷胱甘肽(GSH)含量和肾脏超氧化物歧化酶(SOD)活性无明显影响。钒酸钠处理可使糖尿病大鼠肾脏谷胱甘肽过氧化物酶(GSH—px)活性下降,肾脏脂质过氧化物(LPO)含量上升,使上述二者比值(GSH—px/LPO)降低。这种现象在应用高剂量钒酸钠(0.2mg/ml)更明显。研究结果提示,在应用钒酸盐治疗糖尿病时应采用最低有效剂量,并应考虑伍用对抗钒酸盐过氧化作用的措施。
The effect of chronic oral administration of sodium vanadate on the free radical defense mechanism of diabetic rats was studied. Sodium vanadate was placed in good water at a concentration of 0.1 mg/ml and 0.2 mg/ml, respectively, for 5 weeks. The results showed that sodium vanadate treatment had no significant effect on the content of reduced glutathione (GSH) and superoxide dismutase (SOD) activity in the liver of diabetic rats. Sodium vanadate treatment can reduce the activity of GSH-px in the kidneys of diabetic rats, and increase the content of lipid peroxidation in kidneys (GSH-px/LPO). reduce. This phenomenon is more pronounced when using high-dose sodium vanadate (0.2 mg/ml). The results of the study suggest that the lowest effective dose should be used in the treatment of diabetes with vanadate, and measures against peroxyacidation against vanadates should be considered.