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57岁女性患者,临床诊断系统性红斑狼疮(SLE),抗核抗体、SSA、SSB阳性,无口干和眼干症状,少量蛋白尿是肾脏损害的临床表现,其肾功能正常。肾活检光镜组织学病变轻,仅见肾小球节段轻度系膜增生,但毛细血管袢略僵硬,免疫荧光检查阴性,超微结构观察肾小球基膜内见质膜样结构,个别足细胞胞质突入肾小球基膜,肾小球系膜区、毛细血管袢基膜内皮下及上皮侧均未见电子致密物沉积。诊断符合足细胞内陷性肾小球病。
57-year-old female patient, clinically diagnosed systemic lupus erythematosus (SLE), antinuclear antibody, SSA, SSB positive, no dry mouth and dry eye symptoms, a small amount of proteinuria is a clinical manifestation of renal damage, its renal function is normal. Renal biopsy light microscope histological lesions, only mild glomerular mesangial hyperplasia, but slightly stiff capillaries, immunofluorescence negative, ultrastructural glomerular basement membrane see plasma membrane-like structure, individual Psoas cytoplasm broke into glomerular basement membrane, mesangial area, capillaries 袢 basement membrane subepithelium and epithelial side were no electron density deposition. Diagnosis consistent with podocyte invagination glomerular disease.