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目的：探讨ｎｍ２３基因表达产物（ＮＤＰＫ）在滋养细胞中的表达及其意义。方法：采用免疫组织化学方法，检测经病理证实的正常绒毛（２５例）、葡萄胎（３０例）、侵蚀性葡萄胎（２５例）、绒毛膜癌（２６例）组织中ＮＤＰＫ／ｎｍ２３的表达状况。结果：①５１例滋养细胞肿瘤中ＮＤＰＫ／ｎｍ２３的阳性表达率为１５．７％（８／１５），远低于正常绒毛组织７６．０％（１９／２５），差异有高度显著性（Ｐ＜０．０１）。②葡萄胎、侵蚀性葡萄胎和绒毛膜癌中ＮＤＰＫ／ｎｍ２３的阳性表达率分别为６６．７％、２８．０％、３．９％，差异有显著性（Ｐ＜００５）。③伴有转移的１４例滋养细胞肿瘤中，无１例ＮＤＰＫ／ｎｍ２３阳性表达。④ＮＤＰＫ／ｎｍ２３在葡萄胎中阳性表达率稍低于正常绒毛对照组，差异无显著性（Ｐ＞００５）。结论：ＮＤＰＫ／ｎｍ２３的低表达或不表达与滋养细胞肿瘤的发生、转移、恶性程度及预后密切相关。
Objective: To investigate the expression of nm23 gene product (NDPK) in trophoblasts and its significance. Methods: Immunohistochemistry was used to detect the expression of NDPK / nm23 in normal villi (25 cases), hydatidiform mole (30 cases), invasive hydatidiform mole (25 cases) and choriocarcinoma (26 cases) situation. Results: ① The positive expression rate of NDPK / nm23 in 51 cases of trophoblastic tumors was 15.7% (8/15), which was much lower than that of normal villi tissues (76.0%, 19/25) (P < 0.01). ② The positive rates of NDPK / nm23 in hydatidiform mole, invasive hydatidiform mole and choriocarcinoma were 66.7%, 28.0% and 3.9%, respectively (P <005). In the 14 cases of trophoblastic tumor with metastasis, none of NDPK / nm23 was positive. ④ The positive rate of NDPK / nm23 in hydatidiform mole was slightly lower than that in normal villus control group (P> 0.05). Conclusion: The low expression or non-expression of NDPK / nm23 is closely related to the occurrence, metastasis, malignancy and prognosis of trophoblastic tumor.