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结合生物物理学与生物化学的微细加工技术已可以获得与生物大分子相近的特征尺寸,推动了微图形化技术在药物筛选与新药开发、组织工程、疾病诊断等领域的应用.综述了微图形化技术在生物医学领域的发展,讨论了光刻、软光刻、模板辅助构图、扫描探针加工、喷墨构图、激光诱导图形化等方法,分析了各种方法的优势、局限性与适用范围,指出分辨力与精度、图形化规模、实验加工条件等是选择不同图形化方法的主要依据.而基于生物物理学和生物化学等对纳米尺度的处理过程进行定量分析、进一步提高其生物兼容性及材料适应性、发展适合图形化芯片的体内微环境模拟技术等是微图形化技术进一步发展的方向.
The micro-patterning technology has been applied in the fields of drug screening, new drug development, tissue engineering and disease diagnosis with the micro-processing technology of biophysics and biochemistry, which has similar feature size with biological macromolecules. The development of biomedicine is discussed in this paper. The methods of lithography, soft lithography, template-assisted patterning, scanning probe processing, inkjet patterning and laser induced patterning are discussed. The advantages, limitations and applicability of various methods are analyzed Range, pointed out that the resolution and accuracy, the scale of the scale, the experimental processing conditions are the main basis for the choice of different graphical methods.Becological and biochemical based on the nanoscale processing of quantitative analysis to further improve its biocompatibility Sexual and material adaptability, the development of in vivo micro-environment simulation technology suitable for the graphic chip is the direction of the further development of the micro-patterning technology.