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目的:探讨米索前列醇在宫腔镜检查中软化、扩张宫颈的效果。方法:将行宫腔镜检查的患者200例随机分为两组:米索前列醇组100例,检查前3~18 h阴道后穹隆置米索前列醇片400μg;对照组100例,检查前3~18 h阴道后穹隆置甲硝唑片0.40 g。观察宫腔镜检查中患者人流综合征的发生率,自觉疼痛情况及宫颈软化、扩张情况。结果:宫腔镜检查米索前列醇组人工流产综合征(PAAS)发生率仅为2.0%,对照组为56.0%,米索前列醇组明显低于对照组。VAS评分:米索前列醇组感觉疼痛者减少,疼痛程度明显减轻,差异有显著性意义。宫颈软化情况比较:米索前列醇组扩张宫颈率下降,扩张宫颈所需时间明显缩短,扩张宫颈更轻松,差异有极显著性意义。结论:宫腔镜检查前3~18 h一次性阴道后穹隆置米索前列醇400μg为方便、有效的软化宫颈的理想方法,使该项技术向无痛性迈进了一大步,让患者在心理上更容易接受此项技术操作,更好地体现了“以人为本”的医疗服务宗旨,值得临床推广应用。
Objective: To investigate the effect of misoprostol on hysteroscopy and dilation of cervix. Methods: Two hundred patients undergoing hysteroscopy were randomly divided into two groups: 100 in misoprostol group, 400 in misoprostol group in vaginal posterior vagina 3 ~ 18 h before examinations, 100 in control group ~ 18 h vaginal posterior fornix metronidazole tablets 0.40 g. Observe hysteroscopy in patients with the incidence of flow syndrome, conscious pain and cervical softening and expansion. Results: Hysteroscopic misoprostol group induced abortion syndrome (PAAS) incidence of only 2.0% in the control group was 56.0%, misoprostol group was significantly lower than the control group. VAS score: Misoprostol sensory pain decreased, the pain was significantly reduced, the difference was significant. Cervical softening conditions: misoprostol group cervical dilatation decreased, the time required to dilate the cervix significantly shortened, dilated cervix more easily, the difference was extremely significant. CONCLUSIONS: 400 μg of misoprostol administered in a single vaginal posterior vaginal hysteroscopy 3 to 18 hours prior to hysteroscopy is an ideal and effective method of softening the cervix, making this technology a major step toward painlessness, allowing patients at Psychologically easier to accept this technical operation, better reflect the “people-oriented” medical service purposes, it is worth clinical application.