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本研究应用药物青蒿琥酯片(100mg/片),在血吸虫病流行区鄱阳湖畔的3个自然村669例易感人群中,用双盲法进行预防日本血吸虫病的现场试验.试验对象在接触疫水后第7d开始服药,每wk1次,连服8次.青蒿琥酯剂量为6mg/kg,对照组服等量的安慰剂片.结果,346例服青蒿琥酯片者无1倒粪检血吸虫阳性;而服安慰剂的323例中有15倒粪检阳性,感染率为4.64%,EPG算术均数为312.0±1009.0,几何均数为37.08±5.3.青嵩琥酯的预防保护率为100%.本次试验不良反应轻微,头痛和腹痛的出现率仅1%左右,而且服药组和对照组的副反应出现率相似,各项实验室检查,包括血尿常规、肝肾功能及心电图等服药前后无明显改变.
In this study, the application of artesunate tablets (100mg / tablet), in schistosomiasis endemic Poyang Lake in 669 cases of three natural villages susceptible population, double-blind method for the prevention of schistosomiasis Japonica field test subjects in contact 7d after the onset of water began to take medication, every wk1 times, and even served eight times.Artecotemate dose of 6mg / kg, the control group taking the same amount of placebo tablets.Results, 346 patients taking artesunate tablets without 1 In the 323 placebo-treated patients, 14 fecal positive tests showed that the infection rate was 4.64%, the mean of EPG arithmetic was 312.0 ± 1009.0 and the geometric mean was 37.08 ± 5.3. The protection rate was 100% .This test was mild adverse reactions, headache and abdominal pain occurred only about 1%, and the incidence of side effects in the medication group and the control group were similar, the laboratory tests, including hematuria, liver and kidney function And ECG and other medication before and after no significant change.