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奎尼丁作为心绞痛治疗药已获得广泛应用,其治疗有效血药浓度为2～5μg/ml。通常用其硫酸盐,每6小时服药一次。然而,除硫酸盐外,其他奎尼丁盐类却仅经肠胃道缓慢吸收,能长时间维持有效浓度。奎尼丁葡糖酸盐就是其中的一种长效盐类。作者将奎尼丁硫酸盐与葡糖酸盐进行比较,以服药后,血中奎尼丁浓度为指标,观察疗效,以确定服药次数。在正常的20例健康受试者进行交义试验,即在1周的停药期间分别给予奎尼丁硫酸盐(200mg片剂)及葡糖酸盐(324mg片剂)。并在给药后36小时分别采血,用萤光测定法检测血浆中奎尼丁的浓度。在两药投与量不同的情况下,设奎尼丁的体内动态呈线性反应,即可按两者投药量之比对血药浓度加以校正。
Quinidine as angina pectoris has been widely used, the effective therapeutic concentration of 2 ~ 5μg / ml. Sulfates are usually given every 6 hours. However, other than sulfates, other quinidine salts are slowly absorbed only in the gastrointestinal tract and maintain their effective concentration for a long time. Quinidine gluconate is one of the long-acting salts. The authors will quinidine sulfate and gluconate compared to take the blood quinidine concentration as an indicator to observe the efficacy, to determine the number of medication. In a normal 20 healthy subjects, a crossover test was conducted, that is, quinidine sulfate (200 mg tablet) and gluconate (324 mg tablet) were given during the one-week withdrawal period. Blood samples were obtained 36 hours after the administration, and the concentrations of quinidine in plasma were measured by fluorometry. In the case of different doses of two drugs, given quinidine in vivo dynamic linear response, you can according to the ratio of the two doses of plasma concentration to be corrected.