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目的:观察温脾汤对大鼠腺嘌呤性慢性肾衰竭的防治作用。方法:将SD大鼠随机分为正常组、假手术组、模型组、尿毒清组及温脾汤小、中、大剂量组。尿毒清组及温脾汤小、中、大剂量组,用200 mg/kg腺嘌呤水溶液及尿毒清、温脾汤不同剂量灌胃,共4周。在第2周和第4周时留取每组大鼠的24 h尿液、称重,第4周处死大鼠,取血、留取肾组织。测定尿、血Ca2+、P3+及血SCr、BUN,进行统计学处理。结果:温脾汤组对慢性肾衰竭大鼠的尿、血Ca2+、P3+及血SCr、BUN有不同程度的改善,疗效明显优于模型组。结论:温脾汤对腺嘌呤导致的大鼠慢性肾衰竭有一定的保护作用。
Objective: To observe the preventive and therapeutic effects of Wenpi Decoction on adenine-induced chronic renal failure in rats. Methods: SD rats were randomly divided into normal group, sham operation group, model group, uremic clear group and Wenpi Decoction small, medium and high dose groups. Uremic clearing group and Wenpi Decoction small, medium and high dose group were treated with different doses of 200 mg/kg adenine aqueous solution, uremic Qingwei and warm spleen soup for 4 weeks. At the 2nd and the 4th week, 24-hour urine of each group of rats was taken and weighed. The rats were sacrificed at the 4th week, and the blood was collected and the kidney tissues were collected. Urine, blood Ca2+, P3+, blood SCr and BUN were measured and statistically processed. Results: The Wenpi decoction group improved the urine, blood Ca2+, P3+, blood SCr and BUN of rats with chronic renal failure to varying degrees, and the curative effect was obviously better than that of the model group. Conclusion: Wenpi Decoction has a certain protective effect on adenine-induced chronic renal failure in rats.