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肝窦内皮细胞(liver sinusoidal endothelial cells,LSEC)是肝血窦内一种高度分化的细胞类型,它在肝纤维化的发生、发展中具有重要作用,LSEC功能障碍被认定是多种肝脏疾病的关键因素。目前国内外关于肝纤维化研究主要集中在抑制肝星状细胞(hepatic stellate cells,HSC)活化和加速细胞外基质(extracellular matrix,ECM)水解上,而对LSEC结构和功能在肝纤维化中的作用研究较少。本文就肝纤维化发展中LSEC通过其独特的结构、分泌相关细胞因子和调控HSC的活化等参与肝纤维化过程的研究成果进行总结,综述了近年来关于LSEC对肝纤维化影响及其调控机制的研究进展。
Liver sinusoidal endothelial cells (LSEC) is a highly differentiated cell type in hepatic sinusoids, which plays an important role in the development of hepatic fibrosis. LSEC dysfunction has been identified as a variety of liver diseases The key factor. At present, the researches on hepatic fibrosis both at home and abroad mainly focus on inhibiting the activation of hepatic stellate cells (HSC) and accelerating the extracellular matrix (ECM) hydrolysis, but on the structure and function of LSEC in hepatic fibrosis The role of research less. This article summarizes the research results of LSEC involved in the process of hepatic fibrosis through its unique structure, secretion of relevant cytokines and activation of regulating HSC in the development of hepatic fibrosis, and summarizes the recent studies on the influence of LSEC on hepatic fibrosis and its regulatory mechanisms Research progress.