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目的探讨嘉兴地区HPV感染率及型别分布。方法选择2012年4月-2013年9月在医院妇科门诊就诊的患者,行阴道镜检查后,采宫颈分泌物获取标本送检,进行HPV DNA分子杂交检测,并对检测结果进行分析。结果被检的910例患者中,HPV阳性330例,阳性率为36.26%。HPV基因型分布阳性率居前3位的是HPV16(26.46%)、HPV52型(21.12%)、HPV58型(11.7%)。单一基因型别感染者230例,检出率为69.7%;双重感染者74例,检出率为22.4%;三重及以上感染者26例,检出率为7.9%。结论妇女在不同地区的HPV感染率存在着一定的差异,除地域差异外,还可能与研究人群的选择及检测方法的不同有关。HPV16型感染最常见,高危型持续感染尤其是HPV16时,无论为宫颈炎还是尖锐湿疣患者,应进行随访及动态监测。
Objective To investigate the prevalence and type distribution of HPV in Jiaxing area. Methods From April 2012 to September 2013, patients undergoing gynecological clinic in the hospital were examined by colposcopy. Cervical secretions were collected and examined by HPV DNA hybridization, and the results were analyzed. Results Of the 910 patients examined, 330 were positive for HPV, the positive rate was 36.26%. The top three HPV genotypes were HPV16 (26.46%), HPV52 (21.12%) and HPV58 (11.7%). In 230 cases with single genotype infection, the detection rate was 69.7%; 74 cases were double infection, the detection rate was 22.4%; 26 cases were infected with triple infection or more, the detection rate was 7.9%. Conclusion There are some differences in HPV infection rates among women in different regions. In addition to geographical differences, women’s HPV infection rates may also be related to the choice of study population and the different detection methods. HPV16 infection is the most common, high-risk type of persistent infection, especially HPV16, both cervicitis and genital warts patients should be followed up and dynamic monitoring.