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芥子气LD_(70)中毒后,地塞米松0.35mg/kg腹腔注射,每日1次,中毒大鼠的活存率由29%提高到59%.死亡动物的活存时间也延长了23%,并使症状得到改善,腹泻及口、鼻分泌物明显减少,食量增加,一般状况较好.脏器检查发现,生理盐水对照组肾上腺重量增加57%,颜色变红;而治疗组只增加22%,色较正常.地塞米松合并庆大霉素及青霉素治疗,效果更好.实验结果首次证明适量的地塞米松对大鼠芥子气全身性中毒有一定的治疗作用,但过量反有害处.
After the LD_ (70) mustard poisoning, dexamethasone 0.35mg / kg intraperitoneal injection, once a day, the survival rate of poisoned rats increased from 29% to 59% .The survival time of dead animals also increased by 23% And the symptoms were improved, diarrhea and mouth, nasal discharge was significantly reduced, food intake increased, the general condition is better .On organ examination found that saline control group adrenal weight increased 57%, the color turns red; while the treatment group increased by only 22% , The color is normal.Dexamethasone with gentamicin and penicillin treatment, the effect is better.Experimental results for the first time to prove that the appropriate amount of dexamethasone on rat mustard gas systemic poisoning have a certain effect, but excessive anti-harmful.