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[目的]研究国产盐酸拓扑替康单药治疗小细胞肺癌的疗效及毒副作用。[方法]Topotecan1.2mg/m2,静滴30分钟d1～5 ,每3周重复 ,共2周期 ,并观察疗效及相应的毒副作用。[结果]Topotecan单药治疗总有效率为18% ,对初治患者有效率为40% ,其主要毒性是骨髓毒性。[结论]Topotecan是治疗复发性小细胞肺癌疗效肯定的药物。临床应用以一线治疗为佳 ,二线治疗或耐药的患者宜选用含Topotecan的联合方案。
[Objective] To study the efficacy and toxic side effects of domestic topotecan hydrochloride monotherapy in the treatment of small cell lung cancer. [Methods] Topotecan 1.2mg/m2, intravenous infusion for 30 minutes d1 ~ 5, repeated every 3 weeks, a total of 2 cycles, and observe the efficacy and the corresponding toxic side effects. [Results] The total effective rate of Topotecan monotherapy was 18%, and the effective rate was 40% for untreated patients. The main toxicity was bone marrow toxicity. [Conclusion] Topotecan is an effective drug for the treatment of recurrent small cell lung cancer. It is better to use first-line treatment for clinical use. Patients with second-line treatment or drug resistance should use the combination program with Topotecan.