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目的 通过对Wistar幼鼠维生素A(VitA)缺乏饮食组和正常饮食组对 1,2 二甲基肼(1,2 dimethylhydrazine,DMH)所诱导的肾母细胞瘤成瘤率和肾源性剩余 (nephrogenicrest,NR)检出率的比较 ,证实维生素A对肿瘤形成的影响 ,以及肾源性剩余在肾母细胞瘤发生中的作用。方法建立DMH诱导的Wistar幼鼠的肾母细胞瘤动物模型 ,将其分成二组 ,分别给予正常饮食和维生素A缺乏饮食。 1年内观察肿瘤生成和肾源性剩余形成情况。结果 30只正常饮食组检出肾母细胞瘤 4只 ,占 13.3% (4 /30 ) ,NR数为 2只 ,占 3.3% (2 /6 0 )。 30只VitA缺乏饮食组 ,检出肾母细胞瘤 11只 ,占 36 .7% (11/30 ) ,NR数 10只 ,占 16 .7% (10 /6 0 )。两组成瘤率和NR检出率相比 (χ2 检验 )差别有显著性意义 (P <0 .0 5 )。结论 VitA在肾母细胞瘤的发生中起了重要的作用 ,其缺乏状态可能与肾胚基细胞的分化停止或迟滞有关
Objective To investigate the tumorigenic rate of nephroblastoma induced by 1,2-dimethylhydrazine (DMH) and nephrogen-derived excess (WBC) in the vitamin A deficient diet group and the normal diet group nephrogenicrest, NR), confirming the effect of vitamin A on tumor formation and the role of nephrogenic leftover in nephroblastoma. Methods Animal models of nephroblastoma in Wistar rats induced by DMH were established and divided into two groups, which were given normal diet and vitamin A deficiency diet respectively. 1 year observation of tumor formation and nephrogenic residual formation. Results Thirty nephroblastomas were detected in 30 normal dietary groups, accounting for 13.3% (4/30) and 2 NR (3.3%, 2/60). Eleven VitA-deficient diets were detected in 30 patients with nephroblastoma, accounting for 36.7% (11/30) and 10 NR, accounting for 16.7% (10/60) of them. There was a significant difference between the two groups in tumor formation rate and NR detection rate (χ2 test) (P <0.05). Conclusion VitA plays an important role in the development of nephroblastoma. The lack of VitA may be related to the cessation or delay of the differentiation of nephritic cells