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目的:观察复方卡比多巴片联合补脑熄风止痉汤治疗帕金森病(PD)的疗效及对患者白细胞介素(IL)-6、IL-1β、丙二醛(MDA)、超氧化物歧化酶(SOD)、血清胱抑素C水平的影响。方法:68例PD患者随机分为观察组和对照组,每组34例。对照组使用复方卡比多巴片,观察组在此基础上加以补脑熄风止痉汤治疗。两组疗程均为3个月。比较两组患者治疗前后帕金森病定量表(UPDRS)、生活质量、中医症候、抑郁自评量表(SDS)、焦虑自评量表(SAS)、炎症因子水平变化。结果:治疗后,两组患者的UPDRS-1、UPDRS-2、UPDRS-3评分以及PDQ-39 SI、SDS、SAS及中医症候评分均较治疗前下降(P<0.05),且观察组上述评分明显低于对照组(P<0.05);观察组的UPDRS-4评分也明显低于对照组(P<0.05)。治疗后,两组患者的IL-6、IL-1β、MDA、血清胱抑素C水平均较治疗前显著下降(P<0.05),超氧化物歧化酶(SOD)水平则较前显著提高(P<0.05);且观察组患者的IL-6、IL-1β、MDA、血清胱抑素C水平明显低于对照组,SOD水平明显高于对照组(P<0.05)。观察组总有效率91.18%,显著高于对照组的64.70%(P<0.05)。结论:复方卡比多巴片联合补脑熄风止痉汤治疗PD,能明显改善患者的运动、非运动症状,安全性高,临床疗效较好。
OBJECTIVE: To observe the curative effect of compound cardriodipine combined with Buxu Xifengzhijing decoction on Parkinson’s disease (PD) and its effects on interleukin (IL) -6, IL-1β, malondialdehyde (MDA) Oxide dismutase (SOD), serum cystatin C levels. Methods: 68 patients with PD were randomly divided into observation group and control group, 34 cases in each group. The control group using compound carbidopa tablets, the observation group on this basis to be Bu Ling Xifeng Zhijing treat. Two groups of treatment are 3 months. The changes of the Parkinson’s Disease Rating Scale (UPDRS), quality of life, TCM symptoms, SDS, SAS, and inflammatory cytokines were compared between the two groups before and after treatment. Results: After treatment, UPDRS-1, UPDRS-2, UPDRS-3 and PDQ-39 SI, SDS, SAS and TCM symptom scores of both groups were significantly lower than those before treatment (P <0.05) (P <0.05). The UPDRS-4 score in the observation group was also significantly lower than that in the control group (P <0.05). After treatment, the levels of IL-6, IL-1β, MDA and serum cystatin C in both groups were significantly decreased (P <0.05) and the levels of superoxide dismutase (SOD) P <0.05). The levels of IL-6, IL-1β, MDA and serum cystatin C in the observation group were significantly lower than those in the control group, and the levels of SOD in the observation group were significantly higher than those in the control group (P <0.05). The total effective rate in observation group was 91.18%, which was significantly higher than that in control group (64.70%, P <0.05). Conclusion: The combination of compound carbidopa tablets and buxutan xifengzhijing decoction can significantly improve the patients’ motor and non-motor symptoms, and has high safety and good clinical efficacy.