目的优化1-甲基-3-丙基-4-硝基吡唑-5-甲酰胺的合成工艺。方法运用甲苯溶液作溶剂,并利用单因素和正交设计试验优化方法对甲苯的用量进行优化。结果最佳条件为:甲苯(a)10.9当量、甲苯(b)3.6当量、甲苯(c)7.3当量,产率96.7%。结论优化后的合成工艺使产物稳定性和产率得到提高,适合进行扩大规模生产。 Objective To optimize the synthesis of 1-methyl-3-propyl-4-nitropyrazole-5-carboxamide. Methods Toluene solution was used as solvent, and the amount of toluene was optimized by single factor and orthogonal experimental design. The optimum conditions were as follows: 10.9 equivalents of toluene (a), 3.6 equivalents of toluene (b) and 7.3 equivalents of toluene (c), yield 96.7%. Conclusion The optimized synthesis process can improve product stability and yield and is suitable for expanding scale production.