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目的研究MHCⅠ类链相关基因A(MHCclassⅠchainrelatedgeneA,MICA)第5外显子微卫星多态性与湖南地区鼻咽癌之间的相关性。方法应用荧光聚合酶链反应基因扫描技术和聚合酶链反应序列特异性引物技术分析127例湖南地区鼻咽癌患者和112名正常人群MICA基因第5外显子微卫星等位基因及MICA基因缺失(MICADel)频率。结果MICAA9表型频率在患者组(45/127)高于对照组(20/112),相对风险值(relativerisk)为2.524(P=0.001,Pc=0.006);MICAA5.1表型频率在患者组(51/127)低于对照组(69/112),相对风险值为0.418(P=0.0004,Pc=0.0026)。进一步分析发现,MICAA9在男性患者组的表型频率(35/101)高于男性对照组(11/78),相对风险值为3.23(P=0.00095,Pc=0.006);MICAA5.1在男性患者组的表型频率(39/101)低于男性对照组(49/78),相对风险值为0.372(P=0.0007,Pc=0.004);各MICASTR等位基因频率在女性患者组与女性对照组之间的差异无统计学意义(Pc>0.05)。结论湖南地区MICASTR等位基因多态性与鼻咽癌相关,MICAA9是该人群男性个体的一个鼻咽癌遗传易感标记。
Objective To study the association between MHC class I chain-associated gene A (MICA) exon 5 microsatellite polymorphism and nasopharyngeal carcinoma in Hunan Province. Methods The microsatellite allele and MICA gene of exon 5 of MICA gene in 127 cases of nasopharyngeal carcinoma and 112 normal controls in Hunan Province were analyzed by fluorescence polymerase chain reaction (PCR) and polymerase chain reaction (PCR) sequence-specific primers (MICADel) frequency. Results The frequency of MICAA9 phenotype was higher in patients (45/127) than in controls (20/112), and the relative risk (relativerisk) was 2.524 (P = 0.001, Pc = 0.006) (51/127) was lower than the control group (69/112). The relative risk was 0.418 (P = 0.0004, Pc = 0.0026). Further analysis showed that the MICAA9 phenotype frequency was higher in male patients (35/101) than in male controls (11/78), with a relative risk of 3.23 (P = 0.00095, Pc = 0.006) (39/101) was lower than the male control group (49/78), the relative risk was 0.372 (P = 0.0007, Pc = 0.004). The frequencies of each MICASTR allele in female group and female control group The difference was not statistically significant (Pc> 0.05). Conclusion MICASTR allele polymorphism in Hunan is associated with nasopharyngeal carcinoma. MICAA9 is a predisposing marker of nasopharyngeal carcinoma in males of this population.