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目的：探讨细胞因子与癫癎发病的关系。方法：采用酶联免疫吸附法（ＥＬＩＳＡ） 对５８ 例癫癎患者及４２ 例正常对照血清可溶性白细胞介素２ 受体（ｓＩＬ２Ｒ） 及肿瘤坏死因子（ＴＮＦ） 水平进行了检测。结果：癫癎组血清ｓＩＬ２Ｒ 及ＴＮＦ 水平显著高于正常对照组，血清ｓＩＬ２Ｒ 及ＴＮＦ 水平变化与癫癎类型无关，抗癫癎药物对血清ｓＩＬ２Ｒ 及ＴＮＦ 水平无明显影响。结论：癫癎患者存在内在的细胞免疫功能紊乱，其单核—巨噬细胞及Ｔ淋巴细胞处于激活状态。
Objective: To investigate the relationship between cytokines and epilepsy. Methods: Serum soluble interleukin 2 receptor (sIL 2R) and tumor necrosis factor (TNF) were detected by enzyme-linked immunosorbent assay (ELISA) in 58 epileptic patients and 42 normal controls. Results: Serum levels of sIL2R and TNF in epilepsy group were significantly higher than those in normal control group. Serum sIL2R and TNF levels had no correlation with the type of epilepsy. Antiepileptic drugs had no significant effect on serum sIL2R and TNF levels. CONCLUSIONS: Epileptic patients have inherent cellular immune dysfunction and monocytes - macrophages and T lymphocytes are activated.