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本文提出一个模型研究在心肌兴奋期间心肌细胞膜中钠传导的峰值Vmax成分的变化,并通过Vmax成分的变化而作出某些估计和分析。该模式研究表明并已由令人信服的实验结果所证实了在Vmax的非钠电流是极小的,并且膜电容不会改变。当钠通道传导的最大值(g_(Na))和钠平衡电位(E_(Na))各自独立时,如能合理地估计E_(Na)的初值,我们就可以从Vmax的成分改变来预测g_(Na)和E_(Na)各成分的改变。当E_(Na)为已知时,通过改变静息膜电位而不改变g_(Na),我们能在稳定的Na~+灭活[h_∞(V)]状态下计算g_(Na)的变化。无论其通道是以连续的或非连续形
This paper presents a model to investigate changes in the peak Vmax component of sodium conduction in the myocardial cell membrane during cardiac excitability and to make some estimates and analyzes based on changes in the Vmax component. This model study shows and has been confirmed by convincing experimental results that the non-sodium current at Vmax is minimal and the membrane capacitance does not change. When sodium channel conduction maximum (g Na) and sodium balance potential (E Na) are independent, if we can reasonably estimate the initial value of E Na, we can predict the change from the composition of Vmax g_ (Na) and E_ (Na) changes in each component. When E_ (Na) is known, we can calculate the change of g_ (Na) under the condition of steady Na ~ + inactivation [h_∞ (V)] by changing the resting membrane potential without changing g_ (Na) . Whether its passage is continuous or discontinuous