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胆汁郁积性肝病病人中代谢性骨病常见,但维生素D水平和钙吸收不良在这种骨病发生中的重要性仍未明确。本文对14例并发代谢性骨病的慢性胆汁郁积性肝病病人,研究肠钙吸收及其与维生素D水平之间的关系。对象与方法:14例病人中11例为原发性胆汁性肝硬化,1例为硬化性胆管炎,2例为先天性胆管发育不全。研究时给予随意饮食,平均每日食物中含钙量约500mg。测定血清钙、磷、25羟维生素D、1,25二羟维生素D、甲状旁腺素浓度以及肠钙吸收。肠钙吸收的测定方法是:分别在空腹状态下(相隔24小时)给予病人口服和静脉注射~(47)CaCl_2后测定右前臂的放射活性,并
Metabolic bone disease is common in patients with cholestatic liver disease, but the importance of vitamin D levels and calcium malabsorption in the development of this type of bone disease remains unclear. In this paper, fourteen patients with chronic cholestatic liver disease complicated by metabolic bone disease were studied intestinal calcium absorption and its relationship with vitamin D levels. Subjects and Methods: Of the 14 patients, 11 were primary biliary cirrhosis, 1 was sclerosing cholangitis, and 2 were congenital biliary hypoplasia. Study to give free diet, the average daily calcium content of food about 500mg. Serum calcium, phosphorus, 25 hydroxyvitamin D, 1,25 dihydroxyvitamin D, parathyroid hormone concentration and intestinal calcium absorption were measured. The intestinal calcium absorption was determined by measuring the radioactivity of the right forearm after oral and intravenous injection of ~ (47) CaCl2 into the patient in the fasting state (24 hours apart)