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乙型肝炎（ＨＢＶ）是严重危害人类健康的传染病，在感染了ＨＢＶ的人群中，原发性肝癌的发病率比非感染人群高２００倍［１］。因此研制特异的抗ＨＢＶ药物十分重要。然而ＨＢＶ病毒具有极窄的宿主范围，它仅在人和黑猩猩中感染和复制［２］。Ｕｅｄａ首用细胞系（ＨＢ６１１
Hepatitis B (HBV) is an infectious disease that seriously harms human health. In people infected with HBV, the incidence of primary liver cancer is 200 times higher than that of non-infected people [1]. Therefore, it is very important to develop specific anti-HBV drugs. However, the HBV virus has a very narrow host range and it only infects and replicates in humans and chimpanzees [2]. Ueda first cell line (HB611