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目的:探讨中药清毒栓对宫颈上皮内瘤变(C IN)Ⅰ、Ⅱ级患者血清SccA g的影响。方法:92例C IN-Ⅰ、Ⅱ确诊患者随机分为治疗组和对照组各46例,两组均分别给予清毒栓和-α2b干扰素塞阴治疗20天、40天及60天,分别抽取以上患者的用药前及用药各阶段后晨起空腹血,M E IA法测定血清中SccA g值。结果:1、用药20天时患者两组血清SccA g的含量与用药前比有降低趋势,但无统计学意义。2、用药40天时患者两组血清SccA g的含量与用药前比有明显降低(P<0.05)。3、用药60天后两组患者血清SccA g的含量与用药40天比有降低的趋势,但效果不显著(P>0.05),无统计学意义。4、清毒栓组比-α2b干扰素组血清SccA g的含量略见降低,但无统计学意义。结论:中药清毒栓对C IN-Ⅰ、Ⅱ级患者有一定的预防和治疗作用,可体现在对血清SccA g的含量变化上,值得临床医生推广应用。
Objective: To investigate the effect of Qingdu Suppository of traditional Chinese medicine on serum SccA g in patients with cervical intraepithelial neoplasia (CIN) I and II. METHODS: Ninety-two patients with CIN-I and II were randomly divided into treatment group and control group with 46 cases in each group. Both groups were given Qing Duan Shu and -α2b interferon-Sini therapy for 20 days, 40 days, and 60 days, respectively. The fasting blood of the above patients before and after each phase of drug administration was taken. The serum SccA g value was determined by ME IA method. Results: 1. The serum SccA g levels in the two groups had a decreasing trend compared with those before the drug treatment at 20 days, but there was no statistical significance. 2. The serum SccA g levels in the two groups were significantly lower than those before the administration at 40 days (P<0.05). 3. The serum SccA g content in the two groups after 60 days of treatment was lower than that in the 40 days after treatment, but the effect was not significant (P>0.05). There was no statistical significance. 4. The serum SccA g content in the Qingdu Suppository group was slightly lower than that in the -α2b interferon group, but it was not statistically significant. Conclusion: The Chinese medicine Qingdu Suppository has certain preventive and therapeutic effects on CIN-I and II patients, which can be reflected in the changes of serum SccA g content. It is worthy of clinicians’ popularization and application.