苄基二氢异喹啉类化合物是合成具有特殊药理活性的阿朴菲类、吗啡二烯酮等生物碱的重要中间体,且本身也有很强的药理活性,因此,我们经Bischler-Napieraski法合成一系列的苄基二氢异喹啉类化合物,其中发现一特列反应即:(±)N-(3,4-甲二氧基苯乙基)-α-甲氧基-邻-氯苯乙酰胺(Ⅰ)在成环时α-甲氧基氧化成羰基氧。反应后得到产物Ⅱ,未得到预计产物Ⅱ’.反应式如下: Benzyldihydroisoquinolines are important intermediates for the synthesis of aporphines, morphinedikenes and other alkaloids with special pharmacological activities, and have strong pharmacological activity themselves. Therefore, we have studied the Bischler-Napieraski method A series of benzyldihydroisoquinolines were synthesized, in which a series of reactions were found: (±) N- (3,4-Dimethoxyphenethyl) -α-methoxy- Phenylacetamide (I) is alpha-methylated to form carbonyl oxygen when cyclized. After the reaction, the product II was obtained without the expected product II ’. The reaction formula is as follows: