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为探讨脑溢安颗粒剂治疗急性脑出血的疗效机制，对３８ 例急性脑出血患者采用脑溢安颗粒剂（ 中药组） 和西药（ 西药组） 治疗，观察患者治疗前后血浆中去甲肾上腺素（ ＮＥ） 、肾上腺素（Ｅ） 和多巴胺（ＤＡ）的变化。结果表明：急性脑出血患者血浆中ＮＥ，Ｅ 和ＤＡ 含量均较正常人对照组明显增高（ Ｐ ＜ ０ ．０１） ；而且随着患者脑血出血量的增加或病情的加重而升高。患者经治疗后，中药组血浆ＮＥ，Ｅ 和ＤＡ 含量均较治疗前明显降低（ Ｐ ＜ ０ ．０１） ；而西药组较治疗前降低不明显（ Ｐ ＞ ０ ．０５） ；中药组较西药组明显降低（ Ｐ ＜ ０ ．０１） 。提示脑溢安颗粒剂能有效地降低血浆ＮＥ，Ｅ 和ＤＡ 含量，解除患者脑血管痉挛，减轻脑水肿，改善脑组织微循环，增加组织血供和能量供应，改善脑组织缺血缺氧状态，提高临床疗效。
To investigate the therapeutic mechanism of Nao Yi An granules in treating acute cerebral hemorrhage, 38 patients with acute cerebral hemorrhage were treated with Naoyi granules (Chinese medicine group) and Western medicine (Western medicine group). The patients were observed for plasma norepinephrine before and after treatment. Changes in (NE), epinephrine (E), and dopamine (DA). The results showed that the plasma levels of NE, E, and DA in patients with acute cerebral hemorrhage were significantly higher than those in the control group (P < 0.01), and they increased with the increase of cerebral hemorrhage or aggravation of the disease. After treatment, the plasma levels of NE, E, and DA in the TCM group were significantly lower than before treatment (P < 0.01), while the western medicine group had no significant decrease compared with that before treatment (P > 0.05); the TCM group was better than the western medicine group. Significantly lower (P < 0. 01). Tips Naoyionan granules can effectively reduce the plasma levels of NE, E and DA, relieve cerebral vasospasm, relieve cerebral edema, improve brain microcirculation, increase tissue blood supply and energy supply, and improve cerebral ischemia and hypoxia. Improve clinical efficacy.