目前已知大约有近200种化学药物对哺乳类动物或人类的体细胞具有致染色体断裂的作用。我们在开展职业病的诊治过程中,常见到接触锰粉的工作人员随着接触锰粉工龄的延长,将先后出现神经系统遭受损伤的一系列临床症状,如头晕、头痛、嗜睡或睡眠障碍,记忆力减退、全身疲倦、流涎、多汗、下肢无力、拖步、前冲、后倒、易跌、钝坐、平衡障碍及共济运动失调等。这些症状的出现可因人而异,通常呈进行性发展,也有突发性加剧,这样的变化过程似乎意味着已进入体内的锰盐(MnO_2、MnCl_2、MnO_3等)因排泄慢,在 Nearly 200 chemical agents are known to cause chromosomal damage to mammalian or human somatic cells. During the diagnosis and treatment of occupational diseases, we often encounter a series of clinical symptoms of nervous system damage such as dizziness, headache, drowsiness or sleep disturbance, memory loss Diminished, tiredness, drooling, hyperhidrosis, weakness in lower extremities, tumbling, foregone, after falling, falling, blunt sitting, balance disorders and ataxia and so on. The appearance of these symptoms can vary from person to person, usually a progressive development, but also a sudden increase, this change seems to mean that manganese salts have entered the body (MnO_2, MnCl_2, MnO_3, etc.) due to excretion slow,