心肌中腺苷的形成、嘌呤的释放和前列腺素的形成在缺氧时均增加。腺苷和前列环素(PGI_2)均有扩血管作用。前列环素由于其在冠状血管中形成,提示与冠状循环的调节有关。本文旨在阐明上述作用。方法:48例男性缺血性心脏病患者,年龄在28～69岁。在每例患者冠状窦中插入一根导管,其内有一电极用于心房调搏和一热敏电阻以连续测血 The formation of adenosine in myocardium, the release of purines and the formation of prostaglandins both increase in hypoxia. Both adenosine and prostacyclin (PGI_2) have vasodilator effects. Prostacyclin is involved in the regulation of the coronary circulation due to its formation in coronary vessels. This article aims to clarify the above effects. Methods: 48 male patients with ischemic heart disease, aged 28 to 69 years. A catheter was inserted in each patient’s coronary sinus with an electrode for atrial pacing and a thermistor to continuously measure blood