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0519例麻风,耐药者占29.09％,复发者占10.79％,这主要是由于既往DDS单疗不规则及剂量小所造成。耐药影响麻风的治疗,又有碍于麻风流行的控制,解决的方法是足量、规则地联合使用三种以上的抗麻风药物。联合化疗比DDS单疗疗效明显,且可延缓或防止耐药,对耐药病例也有效。二联和三联治疗麻风的疗效无明显差异,但治疗耐药病例则有显著差异,尤其是对BI2.0以下长期不转阴者三联化疗可促使转阴。为防止耐药病例产生,所有新发现病例均应采用2年以上的联合化疗。DDS、RFP、和PTH的最严重的副反应是全身性剥脱性皮炎和肝脏损伤,一般是在服药后3～6个月内发生,因此在服药中应严密观察,发现严重副反应要马上停药处理。B663除皮肤红染和搔痒及胃肠道反应外,未发现严重副反应。
0519 cases of leprosy, drug-resistant persons accounted for 29.09%, recurrence accounted for 10.79%, mainly due to the previous irregular DDS monotherapy and caused by a small dose. Drug resistance affects the treatment of leprosy and hinders the control of leprosy. The solution is to combine the use of three or more anti-leprosy drugs in sufficient quantity and in a regular manner. Combination chemotherapy than DDS monotherapy significant effect, and can delay or prevent drug resistance, resistant cases are also effective. There was no significant difference between the two groups in the treatment of leprosy and triple therapy, but there were significant differences in the treatment of drug resistance cases, especially for those with long-term non-negative BI 2.0 following chemotherapy. To prevent the emergence of drug-resistant cases, all newly discovered cases should be used more than 2 years of combined chemotherapy. The most serious side effects of DDS, RFP, and PTH are systemic exfoliative dermatitis and liver damage, which typically occur within 3 to 6 months after taking the medication, and should therefore be closely monitored during medication and serious side effects should be stopped immediately Drug treatment. B663 in addition to the skin red and itching and gastrointestinal reactions, no serious side effects were found.