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目的 :探讨人类白细胞抗原 (HLA)的DPB1基因与广州地区汉族人乙型肝炎病毒 (HBV)感染的相关性。方法 :采用测序分型技术 (SBT)对广州地区汉族人中 58例乙型肝炎患者和 75例正常个体的HLA -DPB1基因位点进行了基因分型。结果 :两者的HLA -DPB1等位基因表现型频率差异均无显著性。结论 :本研究检验的广州地区部分汉族人的HBV感染与HLA -DPB1基因无显著相关性
Objective: To investigate the correlation between DPB1 gene of human leukocyte antigen (HLA) and hepatitis B virus (HBV) infection in Han nationality in Guangzhou. Methods: HLA-DPB1 loci were genotyped in 58 hepatitis B patients and 75 normal individuals from Han nationality in Guangzhou by sequencing typing technique (SBT). Results: There was no significant difference in HLA-DPB1 allelic phenotype frequencies between the two groups. Conclusions: HBV infection in our Han population in Guangzhou in our study showed no significant association with HLA-DPB1