【摘 要】
:
Objective: In order to investigate the relationship between the expression of ras gene and the development of hepatocellular carcinoma (HCC). Materials and Meth
【机 构】
:
Guangxi Cancer Institute, Nanning 530021, China;Cancer Institute, Sun Yat-Sen University of Medical
论文部分内容阅读
Objective: In order to investigate the relationship between the expression of ras gene and the development of hepatocellular carcinoma (HCC). Materials and Methods: The experimental tree shrews were divided into four groups: group A, infected human hepatitis B virus (HBV) and exposed to aflatoxin B1 (AFB1); group B, infected human HBV alone; group C, only exposed to AFB1; group D, use as controls. The serial bioptic liver tissues were detected for ras p21 protein using immunohistochemical method. Results: The total p21protein positive rates in group A, B, C and D were 35.3%, 5.3%, 13.3%, 0, respectively, thus the significant difference were showed between group A and group B (P<0.05); The HCC incidences in group A, B, C and D were 47.1%, 0, 13.3%, 0, respectively, and there was a significant difference between group A and C (P<0.05).The incidences of HCC in the animals with and without p21 protein positive in group A were 100% and 18.2%,respectively, and there was a significant difference among them (P<0.01). Conclusion: HBV and AFB1 play a remarkable synergistic role in the development of HCC; they can enhance the expression of ras gene. The over-expression of ras gene is closely related to pathogenesis of HCC in tree shrews.
其他文献
Objective: To study the mechanism of cancer, the DNA for BAC was cloned from an ascites hepatoma cell line Hca-F25/CL-16A3 using PCR. Methods: The nucleotide se
Objective: To understand the relationship between (14; 18) chromosomal translocation and hepatocellular carcinoma. Methods: Semi-nested in situ PCR (SNISPCR) te
Monoclonal antibody (McAb) 3H11 against gastric cancer was grown in the mouse ascites system. To acquire a clinical grade product for cancer radioimmuno-imaging
各位来宾,女士们、先生们:rn很高兴参加2012年新加坡国际水周流域管理论坛,与各位同行进行交流探讨.借此机会,我将介绍淮河流域水利发展情况.rn一、淮河流域基本情况rn淮河流
Objective: To investigate the effects of Ro13-7410on telomerase activity and cell cycle distribution.Methods: Telomerase activity of HL-60 cells induced by reti
Objective: To study the effect of angiogenesis inhibitor TNP-470 on the growth and metastasis of gastric cancer in vivo. Methods: Metastatic model simulating hu
Objective: To establish an efficient and safe gene transfer system mediated by retrovirus for gene marking and gene therapy of human leukemia. Method: The retro
曾被称为“疯牛”的A股市场自6月中旬以来便开始下跌,调整速度和跌幅超出所有人的预料,上证指数下跌近30%,创业板指数跌幅超过40%,很多股票已被腰斩,场外配资纷纷出现爆仓。 目前看,当务之急是市场上下都应该冷静地进行反思,尤其监管部门要反思这次对形势的误判和对杠杆风险的认识不足,未来要尽量减少用“逆周期调节机制”来行政干预市场,别把控制风险变成制造风暴。 曾被称为“疯牛”的A股市场,自今年6月
2015年4月(2015年4月1日零时至4月30日24时),全省共报告法定传染病5,371例,死亡15人。其中,甲类传染病无发病及死亡病例报告。乙类传染病报告11种,共报告发病5,014例,死亡15