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非类固醇类抗炎药(NSAIDs),尤其是阿斯匹林可以减少人结直肠癌和可能的其它胃肠肿瘤发生的证据尚未完全定论.患类风湿性关节炎患者有规律地服用NSAIDs,似乎胃肠肿瘤(主要为胃和大肠癌)的发生率降低.为了确定是否有规律地使用阿斯匹林能减少结直肠癌的危险性,作者在美国卫生职业大组男性中检查了使用阿斯匹林和其它NSAIDs与结直肠腺瘤和癌发生率和死亡率的关系.1986年作者邮寄调查表进行调查,包括阿斯匹林和其它NSAIDs使用情况及癌症史和其它临床上诊断的疾病情况.有47900男性反馈调查表,年龄为40～75岁.1988、1990和1992年通过邮寄随访调查表以修正己知的资料,并确定新诊断的疾病.
The evidence that non-steroidal anti-inflammatory drugs (NSAIDs), especially aspirin, can reduce the incidence of colorectal cancer in humans and possibly other gastrointestinal tumors has not been completely determined. Patients with rheumatoid arthritis regularly take NSAIDs and it seems that The incidence of gastrointestinal cancers (mainly gastric and colorectal cancers) is decreasing. To determine whether regular use of aspirin can reduce the risk of colorectal cancer, the author examined the use of Aspen in the large group of men in the US health professions. Relationship between Pirin and other NSAIDs and colorectal adenomas and cancer incidence and mortality. The authors mailed questionnaires in 1986 to investigate the use of aspirin and other NSAIDs and the history of cancer and other clinically diagnosed diseases. There are 47,900 men’s feedback questionnaires, aged 40 to 75 years old. In 1988, 1990, and 1992, follow-up questionnaires were mailed to correct known data and identify newly diagnosed diseases.