在前期核苷类化合物的研究基础之上,为了进一步改善该类化合物的生物活性,基于几丁质合成酶催化作用机制,通过活性亚结构拼接方法,将具有良好生物活性的氨基甲酸酯基片段引入到前期所设计化合物的硫脲桥当中,设计合成了一系列结构新颖的含酰基氨基甲酸酯基硫脲的核苷类化合物.以尿苷为原料,经4步反应制得目标物,其结构经IR,1H NMR及HRMS确证.初步生测结果表明,部分化合物具有一定的杀菌和杀虫活性,化合物5j对棉铃虫的抑制活性与对照药剂除虫脲相当. Based on the previous studies of nucleosides, based on the mechanism of chitin synthase catalysis, in order to further improve the biological activity of these compounds, carbamate groups with good bioactivity A series of structurally novel nucleosides containing acyl carbamate thioureas were designed and synthesized, which were introduced into the thiourea bridge of the designed compounds in the earlier stage. Uridine was used as the starting material to obtain the target compound , And its structure was confirmed by IR, 1H NMR and HRMS.The results of preliminary bioassay indicated that some of the compounds had certain bactericidal and insecticidal activity, and the inhibitory activity of 5j on Helicoverpa armigera was comparable to that of the control drug diflubenzuron.