给麻醉大鼠一次或恒速静脉注射APⅢ(40μg/kg或4μg/kg·min)可显著降低LVSP,SAP,DAP和MAP。但不明显改变麻醉大鼠的(dP/dt)/P,±(dP/dt)_(max),LVEDP及HR等。恒速静脉输注APⅢ(4μg/kg·min)20min大鼠的尿量平均增加5.2倍。然而侧脑室内给予APⅢ(5和15μg/kg)对麻醉大鼠血流动力学各指标以及尿量均无影响,可见APⅢ对心血管系统及肾脏等靶器官的作用可能没有中枢机制参与。 One-time or constant-speed intravenous injection of APⅢ (40 μg / kg or 4 μg / kg · min) to anesthetized rats significantly reduced LVSP, SAP, DAP and MAP. But did not change the (dP / dt) / P, ± (dP / dt) _ (max), LVEDP and HR in anesthetized rats. The urine output of APⅢ (4μg / kg · min) for 20min was increased 5.2 times on average by constant speed intravenous infusion. However, intracerebroventricular administration of APⅢ (5 and 15 μg / kg) had no effect on hemodynamics and urine output in anesthetized rats, indicating that there may be no central mechanism involved in the effects of AP Ⅲ on target organs such as cardiovascular system and kidney.