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目的了解和田地区维吾尔族(维族)、汉族人群中乙型肝类(乙肝)病毒(HBV) 无症状表面抗原(HBsAg)携带情况。方法随机抽取墨玉县2 597人(维族2 022人,汉族575人)的血液样本,以胶体金标记双抗体夹心法检测乙肝表面抗原(HBsAg)。结果维族人口HBsAg携带率1.48%(30/2022),男性为1.078%(20/1370)、女性为1.59%(10/652),平均年龄35 岁,男女之间无年龄、性别差异;而汉族人口HBsAg携带率为6.09%(30/575)、男性为5.6%(21/372)、女性为4.4%(9/203),男性平均年龄为36.3岁、女性为27.6岁,不同年龄、性别之间存在显著差异,且男性高于女性。本地区维族与汉族人口之间HBsAg携带率存在非常显著性差异(P<0.01)。结论和田地区维族人群中乙肝HBsAg携带率与低感染区一致,而汉族人群感染率与内陆地区中度流行区一致。本地区维吾尔族乙肝感染率偏低可能跟维吾尔族的民俗、饮食习惯及生存环境,HLA 基因频率分布差异等因素有关。作者认为,HLA-Bw41等抗原可能为抗乙肝病毒感染(非易感性)的基因(抗原)。
Objective To understand the status of asymptomatic surface antigen (HBsAg) of Hepatitis B virus (HBsAg) in Uighur (Uighur) and Han populations in Hetian area. Methods Blood samples of 2 597 (Uygur 2 022, Han 575) were randomly collected from Moyu County for detection of HBsAg by colloidal gold-labeled double antibody sandwich method. Results The Uygur population carrying rate of HBsAg was 1.48% (30/2022), 1.078% (20/1370) in males and 1.59% (10/652) in females, with an average age of 35 years. There was no age and sex difference between men and women. Han people The carrying rate of HBsAg in the population was 6.09% (30/575), 5.6% (21/372) in men and 4.4% (9/203) in women. The average age of males was 36.3 years and that of females was 27.6 years, There are significant differences between men and women than women. There was a very significant difference in HBsAg carrier rate between Uygur and Han population in the region (P <0.01). Conclusions The prevalence of HBsAg in the Uygur population is the same as that in the low-prevalence area in the Wada area, while the infection rate in the Han population is consistent with that in the inland areas. The low prevalence of Uygur hepatitis B in this area may be related to the Uyghur folklore, eating habits and living environment, and the frequency of HLA gene distribution. The authors believe that HLA-Bw41 and other antigens may be anti-hepatitis B virus infection (non-susceptible) gene (antigen).