肾上腺素受体广泛存在于中枢和外周各种组织器官,在调节机体功能方面具有重要作用,因而成为药理学领域中颇受重视的课题。1948年 Ahlquist 提出α、β肾上腺素受体的分型概念,促进了特异性拮抗剂的合成。此后,继 Lands 等将β受体分为β_1和β_2两种亚型,1974年 Langer 又把α受体分为α_1和α_2两型,从而揭示递质释放的突触前调节机制。近 Adrenergic receptors are widely found in various tissues and organs of the central and peripheral organs and play an important role in the regulation of the function of the body. Therefore, adrenergic receptors have become the subject of considerable attention in the field of pharmacology. Ahlquist in 1948 proposed the concept of α, β adrenergic receptor typing, promoting the synthesis of specific antagonists. Since then, following Lands and other beta receptors will be divided into two subtypes β_1 and β_2, Langer again in 1974 the α receptors were divided into α_1 and α_2 two types, thereby revealing the neurotransmitter presynaptic regulation mechanism. near