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消化道激素的发现已有80余年历史。1971年首次从绵羊下丘脑中发现生长抑素后,对它的研究进展迅速。1977年Guillemin和Schally因这方面的研究成果而获得了诺贝尔医学奖。1977.9.25～27在西德召开了第一届关于生长抑素的国际会议,大大促进了有关的研究工作。现在已能合成多种生长抑素,并开始应用于临床。 D细胞胃肠道D细胞的分布早在1931年就证实胰岛有D细胞存在,但当时对其功能尚不明确,直到1975年才弄清D细胞主要分泌生长抑素。现已知D细胞在脑肠轴(brain-gut axis)有广泛的分布。消化道的D细胞首先在胃窦粘膜中发现,染色性和超
The discovery of gastrointestinal hormones has been 80 years of history. After the discovery of somatostatin in the hypothalamus of sheep for the first time in 1971, its research is progressing rapidly. In 1977, Guillemin and Schally received the Nobel Prize in Medicine for their research in this field. The first International Conference on Somatostatin was held in West Germany from September 25 to September 27, 1977, which greatly contributed to the research work. Now can synthesis a variety of somatostatin, and began to be used in clinical. D cell gastrointestinal D cell distribution as early as 1931 to confirm islet D cells exist, but its function was not clear until 1975, only to find out that D cells mainly secrete somatostatin. D cells are now known to have a wide distribution in the brain-gut axis. Digestive tract D cells first found in the antral mucosa, staining and ultra