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对中药九里香的两种基原植物九里香(Murrayaexotica L.)和千里香(Murrayapaniculata(L.)Jack)的药效进行对比研究,为其多基原收载的合理性及临床用药的等同性提供参考.根据中药九里香的传统功效,采用小鼠扭体反应模型、大鼠足肿胀模型、小鼠胃排空及小肠推进试验、大鼠急性血瘀模型,系统地评价两种植物的行气止痛、活血化瘀作用.结果显示,九里香和千里香的提取物均能明显抑制醋酸引起的小鼠扭体反应和角叉菜胶引起的大鼠足肿胀,减少足肿胀大鼠血浆中炎症因子IL-6,TNF-α和PGE2的水平,促进小鼠胃排空和小肠推进.上述药效呈剂量依赖性,并且相同剂量的九里香和千里香之间无显著差异.因此,九里香和千里香的提取物在抗炎镇痛和促进胃肠动力药效方面具有一致性和等效性,研究结果为中药九里香多基原植物的药效等效性提供了一定的依据.“,”A comparison of the pharmacodynamic effects of two source plants of Murrayae Folium et Cacumen(MFC),Murraya exotica L.and Murraya paniculata(L.)Jack,was performed in order to supply reference for its multi-source rationality and interchangeability in clinical practice.According to the traditional efficacy of MFC,the effects of promoting Qi,relieving pain,promoting blood circulation and removing blood stasis were systematically evaluated by the models of writhing response in mice,foot swelling in rats,gastric emptying and small intestine propulsion in mice,and acute blood stasis in rats,respectively.The results showed that both M.exotica and M.paniculata could significantly inhibit the writhing reaction induced by acetic acid in mice and the paw swelling induced by carrageenan in rats,reduce IL-6,TNF-a and PGE2 levels in plasma of paw-swelling rats and increase gastric empty rate and intestinal propulsive rate.The above-mentioned effects were dose-dependent,and there was no significant difference between M.exotica and M.paniculata at the same doses.Therefore,M.exotica and M.paniculata had the similar anti-inflammatory,analgesic and gastrointestinal motility promotion effects,which provided a support for the pharmacodynamic equivalence of the multi-source plants of MFC.