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目的探讨新生儿高胆红素血症血清心肌肌钙蛋白I(cTnI)的变化及临床意义。方法分别测定40例高胆红素血症新生儿血清cTnI和肌酸磷酸激酶同工酶MB亚型(CK-MB),并与30例生理性黄疸新生儿进行对照比较。结果高胆红素血症新生儿血清cTnI和CK-MB水平均明显高于对照组(P<0.01);高胆红素血症新生儿中cTnI增高的阳性率(65%)明显高于CK-MB(32.5%,χ2=8.46,P<0.01)。结论cTnI水平检测可作为新生儿病理性黄疸早期心肌损伤的诊断指标,有助于早期诊断和治疗。
Objective To investigate the changes of serum cardiac troponin I (cTnI) in neonates with hyperbilirubinemia and its clinical significance. Methods Serum levels of cTnI and creatine phosphokinase MB subtype (CK-MB) were measured in 40 neonates with hyperbilirubinemia and compared with 30 neonates with physiological jaundice. Results The serum levels of cTnI and CK-MB in neonates with hyperbilirubinemia were significantly higher than those in control group (P <0.01). The positive rate of cTnI in hyperbilirubinemia neonates was significantly higher than that in CK -MB (32.5%, χ2 = 8.46, P <0.01). Conclusion The detection of cTnI can be used as a diagnostic indicator of early myocardial injury in neonatal pathological jaundice, which is helpful for early diagnosis and treatment.