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１材料和方法肾毒血清制备：雄性ＳＤ大鼠肾内质匀浆，免疫新西兰大白兔，获兔抗鼠肾血清。模型制备：雄性ＳＤ大鼠，尿检正常，以正常兔ＩｇＧ加弗氏完全佐剂对鼠进行预免疫，５ｄ后１次静注肾毒血清。正常鼠年龄配对作为对照。观察指标：尿蛋白、血清生化检查包括血肌、...
1Materials and methods Preparation of nephrotoxic serum: The renal homogenate of male Sprague-Dawley rats was immunized with New Zealand white rabbits and rabbit anti-rat kidney serum was obtained. Model preparation: Male Sprague-Dawley rats were urine-tested. Rats were pre-immune with normal rabbit IgG plus Freund’s complete adjuvant, and 5 days later they were intravenously injected with nephrotoxic serum. Normal mice age matched as controls. Observation indicators: urinary protein, serum biochemical examination including blood muscle, ...