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4例脑部肿瘤,2例原发性胶质细胞瘤,2例转移性脑瘤(乳房癌转移1例,支气管上皮癌转移1例)。 4例均于脑瘤放疗过程中出现黑皮病。皮肤变成深棕色,主要为头顶、手、前臂、足和小腿。粘膜无色素变化。从放疗的第三周开始出现色素沉着,逐渐加深。用多巴染色发现,4例皮肤组织学变化相同,表现为黑素细胞明显增加,角朊细胞中的黑色素增多,有时黑素细胞胞浆呈泡沫状。作者认为,可能是由于第三脑室的细胞受到射线照射损伤和持久性破坏,引起促黑素细胞激素的
4 cases of brain tumor, 2 cases of primary glioblastoma, 2 cases of metastatic brain tumor (1 case of breast cancer metastasis, 1 case of bronchial epithelial metastasis). All 4 cases had dermatosis in the course of brain tumor radiotherapy. The skin turns dark brown, mainly on the top of the head, hands, forearms, feet and calves. Mucosal changes did not occur. Pigmentation began gradually from the third week of radiotherapy and gradually deepened. Staining with Dopa revealed that the histological changes of the skin were the same in 4 cases, with a significant increase in melanocytes, increased melanin in keratinocytes, and sometimes melanocyte cytoplasm was foamy. The author believes that it may be due to radiation damage and persistent destruction of cells in the third ventricle that cause melanotropin