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【目的】评估血清硒水平与儿童哮喘之间的相关性。【方法】随机选取本院就诊的82名哮喘儿童,并1∶1配比健康儿童,分别测定其血清硒水平。【结果】哮喘组儿童血清硒水平显著低于对照组[(62.1±10.1)vs(75.3±11.2)μg/L](P<0.05);而硒缺乏患病率则高于对照组(47.6%vs31.7%)(P<0.05)。不同哮喘发作程度的儿童其血清硒水平以及硒缺乏患病率均差异无统计学意义(P>0.05)。儿童血清硒水平与哮喘发作次数曾明显负相关(r=-0.436,P<0.001),而与儿童的年龄、身高以及体重等指标并无显著相关性(P>0.05)。【结论】血清硒可能与儿童哮喘的发生发展有关;硒缺乏可能是儿童哮喘的危险因素。
【Objective】 To evaluate the correlation between serum selenium level and childhood asthma. 【Methods】 Eighty-two asthmatic children were selected randomly from our hospital and 1: 1 matched healthy children were selected for serum selenium level. 【Results】 Serum selenium levels in children with asthma were significantly lower than those in the control group [(62.1 ± 10.1) vs (75.3 ± 11.2) μg / L] (P <0.05) vs31.7%) (P <0.05). Children with different degrees of asthma selenium levels and the prevalence of selenium deficiency were no significant difference (P> 0.05). Selenium levels in children were significantly negatively correlated with the number of asthma attacks (r = -0.436, P <0.001), but not with age, height and weight (P> 0.05). 【Conclusion】 Serum selenium may be related to the occurrence and development of childhood asthma; selenium deficiency may be a risk factor for childhood asthma.